The Saints take on a struggling Everton side, looking to put an end to a two game losing streak.
Everton parted ways with Ronald Koeman after he failed to meet the club’s demand despite going all out on the transfer market.
The Toffees looked solid last term producing power packed high intensity football. However this term, it has been a different tale for them losing six of the twelve opening games.
Caretaker boss David Unsworth is unlikely to get the job permanently, and will have a point to prove after 5-1 defeat in the Europa League.
Meanwhile, Southampton are another side failing to impress their fans this season. The Saints sacked Claude Puel for his conservative style of football but things have not improved this term too.
The hosts have scraped up only 3 wins in the league so far, scoring just nine goals in the process. The poor start puts them fourteenth in the league table, two positions above Everton.
The home crowd needs to be vociferous at the St. Marys if they are to upset a struggling Everton side.
Mario Lemina could make a return after an ankle injury has kept him sidelined for over a month.
Former Chelsea midfielder Oriol Romeu is definitely out after picking up a one match ban for his five bookings. Besides the two midfielders, Saints will also miss defender Matt Targett who is suffering a leg injury.
For the visitors, striker Oumar Niasse will miss the first of his two-games out against the Saints after he received a suspension for diving.
Phil Jagielka (groin) and Morgan Schneiderlin (toe) are also doubtful for the Blues.
Saints: Forster, Cédric, van Dijk, Hoedt, Bertrand, Davis (c), Højbjerg, Tadić, Boufal, Ward-Prowse, Austin.
Toffees: Pickford, Kenny, Baines, Keane, Jagielka (C), Schneiderlin, Gueye, Mirallas, Lennon, Sigurdsson, Calvert-Lewin